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In pre-formulation studies, we characterize the drug candidate for its molecular and material properties such as crystallinity and solubility properties. We will screen variety of biocompatible co-solvents and buffers as well as evaluate role of cyclodextrins and micellar solubilization using surfactants. Furthermore, drug-excipient compatibility as well as use forced degradation studies are performed to examine if any added substances such as antioxidants, chelating agents, and other complexing agents are needed to achieve desired solubility and stability.

Relevant Instruments

DensitometerMETTLER TOLEDODensito 30PX